Press Releases
IntegrateRNA Offers High-quality Oligonucleotide Conjuagted to Facilitate Diagnostic and Targeted Drug Delivery
Aug 20, 2021, 11:36 AM
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IntegrateRNA, the mature division of Creative Biogene, is a leading global provider of complete solutions for RNA discovery with innovative tools and platforms, utilizing the latest technology and proprietary protocols to certify and develop superior and easy-to-use products in order to bring RNA research to new areas. Recently, IntegrateRNA develops a high-quality oligonucleotide conjugated with GalNAc, PEG, cholesterol, peptide, antibody, protein etc. to facilitate diagnostic and targeted drug delivery.
IntegrateRNA utilizes chemical coupling methods to link functional ligands to oligonucleotides including siRNA, ASO, and miRNA to optimize the stability, cellular uptake, and pharmacokinetic characteristics of therapeutic oligonucleotides.
IntegrateRNA provides GalNAc-conjugated oligonucleotides, which contain monovalent/trivalent GalNAc clusters attached to the 3'or 5'end of the oligonucleotide. These conjugates are compatible with DNA, 2'-OMe, 2'-MOE, 2'F oligonucleotides, and include optional phosphodiester or phosphorothioate linkages. To support customers' oligonucleotide therapy research, IntegrateRNA provides GalNAc-siRNA, GalNAc-ASO, GalNAc-antagomiRs and GalNAc coupled nucleic acid therapy. Based on many years of experience in oligonucleotide synthesis, modification and conjugation, IntegrateRNA offers single, di-, tri- or tetra-GalNAc conjugated oligonucleotides. GalNAc conjugates are compatible with various ribose, base, and phosphate bond modifications.
In addition, IntegrateRNA provides cholesterol/cholesterol-TEG conjugated oligonucleotides in which the cholesterol group is attached to the 5'-end, 3'-end, or inside of the oligonucleotide. Based on years of experience in oligonucleotide synthesis and modification, cholesterol groups can be incorporated into modified siRNA, ASO and antagomir to improve their stability and enhance cell uptake. IntegrateRNA provides high-purity and high-quality cholesterol-conjugated siRNA/ASO/antagomir. The RNA platform integrates a variety of chemical modifications in a single conjugate delivery system to solve various challenging obstacles, such as stability, prolonged circulation, target-specific cellular uptake, endosomal escape, and off-target properties of siRNA.
As a global supplier, IntegrateRNA provides high-quality functional PEG and PEG derivatives, which are essential for your PEGylated therapeutic oligonucleotides. Based on an advanced PEGylation platform, IntegrateRNA uses a chemical coupling method to produce customized PEGylated oligonucleotides. In addition, IntegrateRNA provides complete PEGylation method development services, including polyethylene glycol derivative screening, analysis and characterization, bio-conjugation method development and optimization, and PEGylated oligonucleotide production.
“We provide customized oligonucleotide coupling services and always follow a strict QC process, including delivery of COA, MS, HPLC and/or other analysis data of the final product.” said Marcia Brady, she also claimed, “Our RNA synthesis platform is a tool for the in vitro synthesis of a variety of RNAs, including mRNA, tRNA, small RNAs, circular RNA, and lncRNA. Researchers can obtain high purity and high precision RNA fragments for complex functional research and even drug discovery.”
About IntegrateRNA
IntegrateRNA, as the division of Creative Biogene that holds a leading position in providing complete solutions for RNA research, has years of experience in next-generation sequencing and develops microarray platforms that enable researchers to explore the world of RNA on an unprecedented scale, and mapping all RNAs involved in cell life programs, human diseases, and drug discovery.
IntegrateRNA utilizes chemical coupling methods to link functional ligands to oligonucleotides including siRNA, ASO, and miRNA to optimize the stability, cellular uptake, and pharmacokinetic characteristics of therapeutic oligonucleotides.
IntegrateRNA provides GalNAc-conjugated oligonucleotides, which contain monovalent/trivalent GalNAc clusters attached to the 3'or 5'end of the oligonucleotide. These conjugates are compatible with DNA, 2'-OMe, 2'-MOE, 2'F oligonucleotides, and include optional phosphodiester or phosphorothioate linkages. To support customers' oligonucleotide therapy research, IntegrateRNA provides GalNAc-siRNA, GalNAc-ASO, GalNAc-antagomiRs and GalNAc coupled nucleic acid therapy. Based on many years of experience in oligonucleotide synthesis, modification and conjugation, IntegrateRNA offers single, di-, tri- or tetra-GalNAc conjugated oligonucleotides. GalNAc conjugates are compatible with various ribose, base, and phosphate bond modifications.
In addition, IntegrateRNA provides cholesterol/cholesterol-TEG conjugated oligonucleotides in which the cholesterol group is attached to the 5'-end, 3'-end, or inside of the oligonucleotide. Based on years of experience in oligonucleotide synthesis and modification, cholesterol groups can be incorporated into modified siRNA, ASO and antagomir to improve their stability and enhance cell uptake. IntegrateRNA provides high-purity and high-quality cholesterol-conjugated siRNA/ASO/antagomir. The RNA platform integrates a variety of chemical modifications in a single conjugate delivery system to solve various challenging obstacles, such as stability, prolonged circulation, target-specific cellular uptake, endosomal escape, and off-target properties of siRNA.
As a global supplier, IntegrateRNA provides high-quality functional PEG and PEG derivatives, which are essential for your PEGylated therapeutic oligonucleotides. Based on an advanced PEGylation platform, IntegrateRNA uses a chemical coupling method to produce customized PEGylated oligonucleotides. In addition, IntegrateRNA provides complete PEGylation method development services, including polyethylene glycol derivative screening, analysis and characterization, bio-conjugation method development and optimization, and PEGylated oligonucleotide production.
“We provide customized oligonucleotide coupling services and always follow a strict QC process, including delivery of COA, MS, HPLC and/or other analysis data of the final product.” said Marcia Brady, she also claimed, “Our RNA synthesis platform is a tool for the in vitro synthesis of a variety of RNAs, including mRNA, tRNA, small RNAs, circular RNA, and lncRNA. Researchers can obtain high purity and high precision RNA fragments for complex functional research and even drug discovery.”
About IntegrateRNA
IntegrateRNA, as the division of Creative Biogene that holds a leading position in providing complete solutions for RNA research, has years of experience in next-generation sequencing and develops microarray platforms that enable researchers to explore the world of RNA on an unprecedented scale, and mapping all RNAs involved in cell life programs, human diseases, and drug discovery.
