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Recently, New York-based supplier BOC Sciences announced that it has completed the optimization of production process conditions and increased the global supply of pseudouridine and its derivatives to meet the needs of RNA pharmaceuticals field.

RNA is an important molecule in the human body, which can analyze genetic information in human cells. The chemical structure of RNA can be extensively modified. Modified RNA plays a key role in human development and disease occurrence. One of the keys to RNA pharmaceutical technology is to target RNA itself. Studying how special types of chemical modifications in the body's cells regulate the function of RNA can help understand how the abnormal performance of the modification process induces the occurrence of human diseases, thereby promoting the development of RNA pharmaceutical technology.

Pseudouridine is the first modified nucleoside to be discovered and is the most abundant modification on RNA in cells, so it is called the "fifth" nucleoside. Pseudouridine is widely present in many kinds of RNA. Compared with uridine, the bases of pseudouridine and ribose are not connected by N-C bonds but by C-C bonds. Pseudouridine has different characteristics from other bases and can stabilize many DNA structures.

For rRNA

Pseudouridine modification can affect the function of rRNA. Pseudouridine affects the folding of rRNA and the assembly of ribosomes. In addition, pseudouridine can stabilize the higher-order structure of rRNA.

For snRNA

Pseudouridine modification in snRNA is involved in the interaction of RNA and RNA, or RNA and protein. These interactions play a role in the shearing process. Pseudouridine in snRNA plays an important role in snRNP formation, spliceosome assembly and precursor mRNA cleavage.

For mRNA

Using pseudouridine instead of uridine for RNA modification can increase the stability of mRNA, extend the half-life, improve translation efficiency and reduce immunogenicity. In addition, the RNA modification of pseudouridine derivatives helps to further improve mRNA technology. The use of N1-methylpseudouridine can further reduce the immune response caused by foreign mRNA entering the body.

For tRNA

Pseudouridine in tRNA can affect the local structure of the domain where it is distributed, thereby affecting decoding activity, improving the accuracy of translation, and helping to maintain a proper reading frame.

For more information about pseudouridine and its derivatives, please visit the website: https://www.bocsci.com/pseudouridine-and-its-derivatives.html.

About BOC Sciences

BOC Sciences, as the world's leading supplier of pseudouridine and its derivatives, can meet customers' comprehensive needs from milligrams level to ton level, from standard to custom synthesis. The company has a strict quality control system and will conduct a comprehensive analysis and testing of the products before shipment to ensure that each batch of products meets the standards. The company is committed to providing pseudouridine and its derivatives products with competitive prices and on-time delivery, and to ensure recognized quality. Relying on a highly efficient professional team, BOC Sciences has established a good cooperative relationship with scientists and researchers in academia and industry in more than 160 countries or regions around the world.