Press Releases
Acroscell Releases Voltage-gated Potassium Channels to Accelerate The Development of Drug Development
Mar 11, 2022, 14:04 PM
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Acroscell, the electrophysiology platform of Creative Bioarray, is a global leading provider of cardiac & neuronal safety profiling and translational assays that can be applied in pharmaceutical, and biotechnology industries. With the cutting-edge electrophysiological screening platform, Acroscell can provide a diverse portfolio of standard and customized drug safety & pharmacology assays and panels for drug screening and profiling. Recently, Acroscell announced the release of its voltage-gated potassium channels to accelerate the development of drug development.
The team at Creative Bioarray has extensive drug discovery capabilities, expertise, and proven experience to successfully meet a variety of project goals, including delivering high-quality data and on-time performance. In addition to drug screening tests (ion channels, GPCRs receptors, and other exchanges and transporters, etc.), Creative Bioarray's assays can reveal specific abnormalities in many genetic models of human cardiovascular and brain disease, as well as the impact of new molecules on bodily functions.
As an experienced electrophysiological laboratory expert, Creative Bioarray provides you with preliminary screening and functional analysis assays to help you discover potential compounds targeting ion channels. Creative Bioarray can help customers analyze the relationships and interactions between compounds and ion channel targets. Creative Bioarray has the most advanced gold standard manual patch-clamp technology, based on a variety of automated platform assays, capable of meeting different needs.
Creative Bioarray has developed fully validated screening and analytical assays and libraries of stable channel expressing cell lines for high-throughput screening, lead optimization studies and selective analysis. All tests are validated by experienced electrophysiologists under strictly optimized SOPs to guarantee the highest quality and consistent data.
Functions of K+ channels include neural integration, pacemaker production, muscle contraction, and hormone secretion in excitatory cells, as well as processes such as cell proliferation, cell volume regulation, and lymphocyte differentiation. The study found that Kcns2 itself does not have potassium channel activity, but participates in vivo activities by regulating the α subunit of Kv2 ion channel. That is, the activation kinetics and voltage dependence of Kv2.1 currents are altered by this expression of Kv9.2. Therefore, the function of Kv9.2 is consistent with the Kv2 ion channel it controls.
“Potassium channels provided by Creative Bioarray can be used to treat a variety of congenital diseases, multiple sclerosis, neuropathic pain treatment and assessment of heart disease risk.” said Hannah Cole, the marketing director of Creative Bioarray, she also added, “We have a comprehensive cell bank with several specialized and unique stable cell lines expressing ion channels that are immediately applicable to a variety of in vitro studies and in vivo pharmacology studies. For any specific requirements, we are capable to offer customized solutions.”
About Acroscell
As a mature division of Creative Bioarray, Acroscell definitely will be the ideal and reliable innovation partner in research endeavors. With the support of professional scientists and years of experience, We are capable to provide a knowledgeable, collaborative and flexible service to our clients so as to accelerate drug development and improve research quality for worldwide projects.
The team at Creative Bioarray has extensive drug discovery capabilities, expertise, and proven experience to successfully meet a variety of project goals, including delivering high-quality data and on-time performance. In addition to drug screening tests (ion channels, GPCRs receptors, and other exchanges and transporters, etc.), Creative Bioarray's assays can reveal specific abnormalities in many genetic models of human cardiovascular and brain disease, as well as the impact of new molecules on bodily functions.
As an experienced electrophysiological laboratory expert, Creative Bioarray provides you with preliminary screening and functional analysis assays to help you discover potential compounds targeting ion channels. Creative Bioarray can help customers analyze the relationships and interactions between compounds and ion channel targets. Creative Bioarray has the most advanced gold standard manual patch-clamp technology, based on a variety of automated platform assays, capable of meeting different needs.
Creative Bioarray has developed fully validated screening and analytical assays and libraries of stable channel expressing cell lines for high-throughput screening, lead optimization studies and selective analysis. All tests are validated by experienced electrophysiologists under strictly optimized SOPs to guarantee the highest quality and consistent data.
Functions of K+ channels include neural integration, pacemaker production, muscle contraction, and hormone secretion in excitatory cells, as well as processes such as cell proliferation, cell volume regulation, and lymphocyte differentiation. The study found that Kcns2 itself does not have potassium channel activity, but participates in vivo activities by regulating the α subunit of Kv2 ion channel. That is, the activation kinetics and voltage dependence of Kv2.1 currents are altered by this expression of Kv9.2. Therefore, the function of Kv9.2 is consistent with the Kv2 ion channel it controls.
“Potassium channels provided by Creative Bioarray can be used to treat a variety of congenital diseases, multiple sclerosis, neuropathic pain treatment and assessment of heart disease risk.” said Hannah Cole, the marketing director of Creative Bioarray, she also added, “We have a comprehensive cell bank with several specialized and unique stable cell lines expressing ion channels that are immediately applicable to a variety of in vitro studies and in vivo pharmacology studies. For any specific requirements, we are capable to offer customized solutions.”
About Acroscell
As a mature division of Creative Bioarray, Acroscell definitely will be the ideal and reliable innovation partner in research endeavors. With the support of professional scientists and years of experience, We are capable to provide a knowledgeable, collaborative and flexible service to our clients so as to accelerate drug development and improve research quality for worldwide projects.
