Creative Biostructure, a biotech company specialized in providing contract services in the field of structural biology, recently released Cryo-EM for gene therapy.

Unlike crystallographic methods, Cryo-EM does not require a crystallization step and can directly visualize biomolecules with minimal sample preparation. This makes Cryo-EM a powerful tool for structural characterization. As a key step in gene therapy, Cryo-EM has been used as a powerful tool for structural characterization of viruses. The two adenoviruses, C adenovirus and D adenovirus, have the same shell core. But the researchers found by using Cryo-EM that they have very different surface structures, called decorations or caps, which are key to the behavior of the virus. Their surface structure determines which receptors on human cells the virus binds to. Therefore, the unique surface structure of adenoviruses can help to target the delivery of viruses, and can be used for the development of vaccines in gene therapy.

Backed by years of experience, Creative Biostructure offers transmission electron microscopy (TEM) analysis of gene therapy and drug delivery particles. Based on its EM platforms, analysis package at Creative Biostructure includes but are not limited to:

• General morphology
• Level of aggregation
• Size distribution
• Circularity
• Packaging
• Lamellarity
• Membrane thickness
• Protein localization 

“The facility at our company is home to world class equipment including negative staining EM, SEM and cryo-TEM that enable our customers to complete in-depth investigations of material properties, including crystallinity, defects, and microstructure. We strive to provide you expertise necessary for success in your research and development projects.” Commented the representative speaker from Creative Biostructure.

In addition to Cryo-EM for Gene Therapy, Creative Biostructure provides:

l  High-speed 4D UEM diffraction analysis, which is a benefit of a high-speed camera.

l  Immunoelectron microscopy services that allow the client to identify antibody/antigen complexes that localize to a particular subcellular organelle or compartment.

l  Cryo-ET that is able to bridge the gap between ultrastructural compartmentalization and the structural analysis of molecular inhabitants.

If you would like to know more detailed information about the Cryo-EM for Gene Therapy service, please visit https://www.creative-biostructure.com/cryo-em-services_4.htm.

About Creative Biostructure

Creative Biostructure is specialized in providing contract services to both academia and biotech/pharmaceutical industries in the field of structural biology. The company offers insightful strategies and cost-effective services on structure determination of macromolecules using X-ray Crystallography, EM, NMR, etc.