Biopharma PEG’s monodisperse PEG products are produced via very reproducible chemical reactions. Monodisperse PEGs lack the polydispersity of traditional PEG polymers. Our monodispersed PEGs retain the polyethylene glycol’s good solubility in water, offering to PEGylated drugs the same PEG benefits of reduced aggregation and immunogenicity, and increased hydrodynamic volume.

Monodispersed PEG linkers have been found to be beneficial in drug design, specifically in small molecule drugs. Some of the problems that are often seen in small molecule drugs include its ability to be easily removed from the body, low solubility and less target-specificity. The introduction of monodispersed PEG linkers to small molecule drugs increases the drug’s solubility and molecular weight. This may allow an extended drug half-life in the body. The use of monodispersed PEG linkers has also improved drug development with its ability to produce homogeneous PEGylated drugs with a specific molecular weight.

Biopharma PEG’s catalog monodisperse PEG products consist of linear chains of 1 to 36 –CH2-CH2-O– units, and various terminal functional and reactive groups. Monodisperse PEG products with molecular weights up to 5000 Da, and possible larger, and functional groups not listed in our online catalog may be available by custom synthesis.

Biopharma PEG provides GMP grade PEG derivatives and bulk orders via custom synthesis, offering the opportunity to match customers’ special quality requirements. We are capable of development and synthesis of a wide range of GMP monodisperse PEG derivatives starting at 200g up to 15 kg or greater batches.

About Biopharma PEG

Biopharma PEG is committed to supplying high quality polyethylene glycol (PEG) derivatives, PEG copolymers and PEG raw materials for the research of universities, research institutions, biotechnology companies and pharmaceutical companies to meet the needs of the vast majority of customers. We also provide professional monodisperse PEG synthesis and PEGylation services with fast turnaround time and high quality. We cater to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.