Biopharma PEG, a leading supplier for PEG derivatives, offers PEG lipids for use in lipid nanoparticles (LNP) systems for mRNA vaccine delivery. These PEG derivatives are of high purity and can be provided in non-GMP and GMP grades.

An mRNA vaccine introduces mRNA encoding a disease-specific antigen into the body and uses the host cell's protein synthesis mechanism to produce the antigen, which triggers an immune response. When a virus eventually invades, the immune system recognizes the specific antigen and then rapidly and specifically fights the virus to prevent the body from being infected.

The large molecular weight, high hydrophilicity, and high bioactivity of mRNA, however, its single-stranded structure makes it extremely unstable and susceptible to degradation, and delivery across cell membranes with the same negative surface charge is also a challenge. A special modification or wrapping delivery system is required to achieve intracellular expression of mRNA.

The commonly used delivery means is lipid nanoparticles (LNP) as a carrier for mRNA delivery. mRNA molecules are protected by LNP and delivered to cells without being first destroyed by the immune system. LNP contains four main components: ionizable cationic lipids, neutral co-lipids, cholesterol, and polyethylene glycol-modified lipids (PEG lipids).

“Currently, COVID-19 mRNA vaccines from Moderna, CureVac, and BioNTech are delivered with lipid nanotechnology (LNP). And, many mRNA vaccines in the pipeline are also using LNP systems,” said the chief scientist of Biopharma PEG, “PEG lipids can have multiple effects on the properties of lipid nanoparticles, such as increasing particle stability by decreasing particle aggregation and prolonging the blood circulation time. We can provide lab and GMP grade PEG products for LNP delivery systems!”

• MF001317 mPEG-DMG
• MF001318 mPEG-N,N-Ditetradecylacetamide (ALC-0159)
• LP096282 DSPE-PEG-Mannose
• MF001096 mPEG-DSPE
• MF001098 mPEG-DPPE
• MF001002 mPEG-OH
• MF001121 mPEG-AA (mPEG-CM)
• MF001170 mPEG-CH2CH2CH2-NH2

If you want to know more details about PEG lipids for LNP system or have any other questions about our research materials, please visit Biopharma PEG at https://www.biochempeg.com/.

About Biopharma PEG

As a leading manufacturer of PEG derivatives, Biopharma PEG is fully competent and dedicated to serving mRNA vaccine companies with high purity PEG lipids. With comprehensive and advanced platforms, the company provides PEG derivatives and related products to customers worldwide to meet new drug delivery goals.