Creative Biogene has recently updated its targeted gene knockout services for C. elegans using the Mos1-mediated deletion method, allowing researchers to delete up to 25 kb of DNA and simultaneously insert a positive selection marker.

C. elegans has many advantages (small in size, short life cycle, easy to feed, etc.) to be used as a research model. Hence, the C. elegans model system enables researchers to study the molecular mechanisms of metabolic diseases, evaluate compounds and drugs, assess the soil and water environment, and screen for different diseases and probiotics in the gut. The Mos1-mediated deletion (MosDEL) strategy is based on the Mos1 transposon to achieve targeted deletion in the genome. Through this strategy, essential genes can be deleted and balanced out at the same time.

Creative Biogene, as one of the leading experts in the field of C. elegans research, has developed a series of systematic platforms to provide a comprehensive suite of C. elegans model services. In order to explore the specific function and expression mechanism of genes, its scientists can design, construct, and deliver genetically edited C. elegans according to customers' specifications. By applying the MosDEL technique, the company can delete or alter specific parts or genes rather than the entire genome.

For C. elegans MosDEL projects, Creative Biogene's experts will start with collaborating on the project design to ensure transparency in every genome editing step and guarantee that clients will receive the best suited transgenic organisms for their experiments. Then its experts carry out high-throughput screening and recover homozygous deletion mutants. Upon accomplishing the C. elegans MosDEL, the final C. elegans model and validation reports will deliver to customers for further strain quality assurance.

The marketing manager of Creative Biogene said, "Our C. elegans MosDel services are customized based on your gene editing needs and requirements. We can ensure accurate final strains based on our systematic platform that knockout target genes in C. elegans using the MosDEL strategy within a short turnaround time and low prices."

About Creative Biogene

Creative Biogene is a reliable partner dedicated to accelerating customers' research projects. It has recruited a professional team with rich experience in the field of C. elegans and advanced instruments, enabling Creative Biogene to develop a series of systematic platforms and complete independent research. It provides a comprehensive suite of services, including experimental consulting, design, execution, management, analysis, and reporting service. In addition, Creative Biogene can also deliver partners with unique products and professional technical support.