Creative Biostructure, a biotech company with years of experience in EM imaging, have built an iEM Platform, providing one-stop solution for bacteriophage structural analysis.

Viruses that infect bacteria and archaea (also known as bacteriophages or phages) have a significant impact on ecosystems. A large number of bacteriophages have been found in seawater. Phage communities represent a significant reservoir of uncharacterized genetic diversity, making them a valuable resource for the advancement of modern biotechnology. Cryo-electron microscopy (cryo-EM) is a powerful structural technique that has recently been developed for the study of biological macromolecular complexes. Cryo-EM is distinguished by its ability to produce relatively high-resolution images and natural conformation analysis without the use of crystallization. This powerful technology has evolved into a practical and sophisticated tool for structural analysis of bacteriophages.

Now at Creative Biostructure, the most advanced electron microscopy equipment and direct electron detectors are available to assist researchers gain insight into the ultrastructure of bacteriophages and promoting a variety of research and applications of bacteriophages.

Specific services include:

Identification of the basic structure of bacteriophages

Determine the structure of bacteriophages at a 3-5 Å resolution range. And reveal the ultrastructure of bacteriophages, such as the structure of the major coat protein and assembly of the capsid shell.

Structural comparisons with other bacteriophages

Structural comparisons of the major coat proteins of different bacteriophages

“We can offer expertise throughout the process from isolation and purification of bacteriophages, sample preparation for cryo-EM, data acquisition, image processing, to structural analysis.” Said Joanna, the chief marketing staff at Creative Biostructure. “Our iEM Platform can offer detailed and valuable information on bacteriophage structures, including but not limited to the major coat protein and the symmetry of the capsid shell.”

For more information about the iEM Platform for bacteriophage research, please visit https://iem.creative-biostructure.com/bacteriophage-research-using-the-iem-platform.html.