IntegrateRNA, the division of Creative Biogene, is a leading global provider of complete solutions for RNA discovery, expression analysis, functional research, and mechanism analysis. IntegrateRNA is dedicated to developing unique technologies and high-quality products to better understand human diseases, explore potential treatments for high-impact diseases, and promote the development of the RNA research field. Recently, IntegrateRNA announced the release of its custom production of peptide-oligonucleotide conjugatesto optimize therapeutical research.

With combined expertise in synthesis, modification, and bioconjugation, IntegrateRNA offers custom production of high-quality and high-yield peptide-oligonucleotide conjugates (POCs). Based on a strict quality assessment and quality control system, each POC is carefully monitored during synthesis, purified by HPLC, and QC tested by mass spectrometry or gel electrophoresis.

The services provided by IntegrateRNA mainly include:

Cell Penetrating Peptide (CPP) Conjugated Oligonucleotides

CPPs are short peptide sequences, typically no longer than 30 residues, that have the ability to cross cell membranes, facilitate endosomal escape and deliver covalently linked nucleic acids into cells. The CPP conjugation strategy has been widely used in oligonucleotide delivery, including siRNA, PMO, PNA, etc. IntegrateRNA has the ability to synthesize and conjugate a variety of CPPs, including common CPPs and tissue-specific CPPs.

Circular RGD-conjugated oligonucleotides

Cyclic RGD (cRGD) peptides are one of the most successful examples of targeting peptides. cRGD binds to αVβ3/5 integrins expressed at high levels in tumor cells and vascular endothelial cells. Conjugation of this peptide to oligonucleotides facilitates the accumulation and expression of the biological activity of RNA in tumor cells in vivo and in vitro. Therefore, cRGD-conjugated oligonucleotides are highly targeted to tumor cells and tissues. IntegrateRNA provides customers with custom cRGD-conjugated oligonucleotides with desired modifications.

“We provide one-stop solutions including oligonucleotide synthesis, modification, and conjugation.” said Marcia Brady, the marketing director of Creative Biogene, she also added, “Our conjugation strategies are designed according to the properties of the target biopolymer and the customer's intended use.”

About Creative Biogene

Creative Biogene, as a top-of-its-kind company that holds a leading position and is committed to accelerating the development of human science through biotechnology, offering innovative technologies, products, unique tools and services for research discoveries and product development. With more than 10 years of experience and in-house experts, Creative Biogene has become a well-recognized industry leader to support researchers worldwide.