By Clinical Research Staff

July 24, 2024 | Cardurion Pharmaceuticals raises $260 million  to support later-stage clinical trials with the company’s two lead drug candidates; CatalYm adds $150 million for phase 2b studies targeting checkpoint-naive and second-line treatment settings for solid tumors; and more.   

$372M: Series D for AI Expansion and Acquiring Candidate Drugs 

Formation Bio raised $372 million in Series D funding, led by a16z with significant participation from Sanofi. Other investors include Sequoia, Thrive, Emerson Collective, Lachy Groom, SV Angel Growth, and FPV Ventures. The company takes an AI-enabled approach to drug discovery and clinical trials. The new capital will be used to acquire candidate drugs and expand their AI capabilities.

$277M: Series D for Genomics Innovator 

Element Biosciences secured $277 million in Series D to support its growing global customer base with disruptive DNA sequencing and multi-omics technologies for years to come. The oversubscribed round was led by Wellington Management with participation from new and existing investors, including Samsung Electronics, Fidelity, Foresite Capital, as well as funds and accounts advised by T. Rowe Price Associates, Inc, and Venrock, among others. This funding will support the commercialization of AVITI and the upcoming launch of AVITI24, the first instrument to combine state-of-the-art sequencing and cyto-profiling (mapping cell characteristics) into a single integrated biology platform. AVITI24 revolutionizes research by enabling simultaneous examination of DNA, RNA, proteins, phosphoproteins, and cell structure within single cells.

$260M: Series B for Cardiovascular Therapies 

Cardurion Pharmaceuticals raised $260 million in Series B funding led by Ascenta Capital, with participation from Bain capital Life Sciences and Bain Capital Private Equity. There was also participation from new investors NEA, GV, Fidelity Management & Research Company, Millennium Management, Farallon Capital Management, Invus, Blue Owl Healthcare Opportunities, Delos Capital, and Digitalis Ventures. The funds will be used to support later-stage clinical trials with the company’s two lead drug candidates, a first-in-class phosphodiesterase-9 (PDE9) inhibitor for heart failure and the first clinical-stage Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) inhibitor with broad therapeutic potential. In addition, the funding will be used to expand the cardiovascular indications for Cardurion’s portfolio of drug candidates, to progress internal discovery programs, and to acquire additional therapeutic assets targeting unmet needs in the cardiovascular disease area.

$150M: Series C for Identifying Novel Cancer Targets 

Scorpion Therapeutics closed a $150 million Series C round led by Frazier Life Sciences and Lightspeed Venture Partners, with contributions from Omega Funds, Vida Ventures, Atlas Venture, Abingworth, Fidelity Management & Research Company, Boxer Capital, EcoR1 Capital, LLC, Surveyor Capital (a Citadel company), Invus, Wellington Management, Nextech Invest Ltd. (on behalf of one or more funds managed by it), OrbiMed, Logos Capital, Woodline Partners LP, and Casdin Capital, LLC.  Additional new support was also provided by Willett Advisors. The proceeds will be used to advance Scorpion's pipeline of differentiated small molecule oncology programs to expand clinical development of its allosteric, differentiated, mutant-selective PI3Kα inhibitor, STX-478.  

$150M: Series D for Monoclonal Antibody Trials 

CatalYm raised $150 million in Series D funding, led by Novartis Venture Fund and Jeito Capital, as well as new investors Canaan Partners, Bioqube Ventures, Omega Funds, Forbion Growth Fund, and Gilde Healthcare. The funds will be used to expand CatalYm’s lead candidate, visugromab, and its late-stage clinical development, including randomized phase 2b studies targeting checkpoint-naive and second-line treatment settings for solid tumors.

$122M: Series A for Liver Disease and Pregnancy Trials 

NGM Biopharmaceuticals announced a $122 million Series A financing led by TCG. NGM Bio will use the proceeds to initiate a planned registrational trial of aldafermin, an engineered FGF19 analog, for the treatment of primary sclerosing cholangitis (PSC), a rare liver disease that irreparably damages the bile ducts, and to complete a planned Phase 2 trial of NGM120, a GDF15/GFRAL antagonist, for the treatment of hyperemesis gravidarum (HG). Both trials are expected to begin in the fourth quarter of 2024.

$115M: Series A for Novel Cancer Treatments 

Myricx Bio raised $115 million in Series A funding, co-led by Novo Holdings and Abingworth, as well as new investors Eli Lilly, Cancer Research Horizons, and British Patient Capital, a subsidiary of the U.K. government’s economic development bank. Founding investors Sofinnova Partners and Brandon Capital also participated in the round. The funds will be used to build out Myricx’s proprietary N-Myristoyltransferase inhibitor (NMTi) antibody-drug conjugate (ADC) payload platform and advance its pipeline of NMTi-ADCs through the proof-of-concept stage. According to Myricx, NMT is an enzyme that can add a lipid modification to several protein targets that are necessary for cancer cell survival.

$100M: Series C for Neurodegenerative Disease Therapies 

Asceneuron secured a $100 million Series C financing to advance the clinical development of its clinical pipeline of OGA inhibitors for the treatment of neurodegenerative diseases. The financing was led by Novo Holdings with new investment from EQT Life Sciences – LSP Dementia Fund, OrbiMed and SR One, alongside participation from existing investors M Ventures, Sofinnova Partners, GSK Equities Investments Limited and Johnson & Johnson Innovation – JJDC, Inc. The financing will be used to advance Asceneuron’s lead asset ASN51 into Phase 2 clinical development for the treatment of Alzheimer’s disease. ASN51 is an oral small molecule drug designed to inhibit OGA, an enzyme implicated in protein aggregation.

$82M: Series A for Genomic Medicines 

Exsilio Therapeutics has closed $82 million in Series A financing. The funding was co-led by Novartis Venture Fund and Delos Capital, with participation from OrbiMed, Insight Partners, J.P. Morgan Life Sciences Private Capital, CRISPR Therapeutics, Innovation Endeavors, Invus, Arc Ventures, and Deep Insight. Exsilio was seed-funded by OrbiMed. The proceeds will be used to advance its genomic medicines based on naturally occurring, programmable genetic elements that can precisely insert new genes into a cell through mRNA intermediates.

$80M: Series B for Computational Disease Models 

CytoReason secured an aggregated $80 million Series B funding from OurCrowd, NVIDIA, Pfizer, and Thermo Fisher Scientific. This investment will be used to expand the application of computational disease models for predictive insights into additional indications, grow its proprietary molecular and clinical data, and establish an office in Cambridge, Mass. later this year.  

$68M: Series A for Inflammatory Disease Treatments 

SciRhom has raised $68 million in Series A funds. The round was co-led by Andera Partners, Kurma Partners, Hadean Ventures, MIG Capital, and Wellington Partners, with participation from new investor Bayern Kapital and existing backers including High-Tech Gründerfonds and PhiFund Ventures. The investment will support clinical development of the company's lead antibody candidate SR-878, which is directed against a protein many experts initially dismissed as an improbable therapeutic target.

$60.3M: Series B for Gout Treatment 

GRO Biosciences closed an oversubscribed $60.3 million Series B financing  co-led by new investors Atlas Venture and Access Biotechnology, as well as participation from previous investors Leaps by Bayer, Redmile Group, Digitalis Ventures, and Innovation Endeavors. Proceeds from the financing will be used to advance the company’s lead program into the clinic for the treatment of refractory gout, to broaden the GRObio pipeline, and to expand its genomically recoded organism (GRO) platform for scalable production of therapeutics incorporating multiple non-standard amino acids (NSAAs).

$37M: Series A for Chronic Hepatitis B Treatment 

AusperBio has completed a $37 million Series A financing round. This round was led by existing investor, InnoPinnacle Fund, with participation from new investors including Yuanbio Venture Capital, Qiming Venture Partners, Hankang Capital, and Genesis Capital. The proceeds from the financing will further support the clinical development of AHB-137, AusperBio's lead product candidate. Additionally, the funds will advance its proprietary Med-Oligo technology platform and its product pipelines.

$35M: Series A for siRNA Programs Development 

Rona Therapeutics announced the completion of $35 Million Series A+ financing. This round was led by LongRiver Investments, with participation from investors including Zhaode Investment, BioTrack Capital, Zhongqi Capital and Lilly Asia Ventures. Rona will use proceeds to progress leading metabolic siRNA pipeline programs into global development and expand extra-hepatic delivery platform in CNS and beyond.

$22.5M: Series B for Commercialization of At-Home Diagnostic Tests 

NOWDiagnostics raised $22.5 million in Series B financing. Led by DigitalDx Ventures, with notable investors including the Labcorp Venture Fund and Kompass Kapital Management, this oversubscribed funding round will be used to drive the commercialization of at-home diagnostic tests, continue developing new diagnostic innovations, expand the pipeline of tests, and support strategic hiring initiatives.

$20M: Series C for Chemoproteomics Platform 

Frontier Medicines closed an oversubscribed $20 million in Series C funding from ArrowMark Partners and Deep Track Capital. The financing proceeds will support further advancement of Frontier’s FMC-376, a small molecule with a differentiated dual direct mechanism of action targeting both ON + OFF KRASG12C that is currently in the Phase 1/2 PROSPER trial (NCT06244771), and other preclinical/pipeline programs against high-value precision medicine targets.

$16.5M: Series A for Customer Relationship Management Platform 

Courier Health announced a $16.5 million Series A led by Norwest Venture Partners with participation from existing investor Work-Bench. The funding will support continued product innovation and hiring across engineering and sales to bring the company's purpose-built customer relationship management (CRM) platform to more biopharma partners in search of a comprehensive system for coordinating and personalizing the patient journey.

$16M: Series A for Oral Therapeutics 

Holoclara announced the completion of an oversubscribed $16 million Series A financing led by BOLD Capital Partners. Horizons Ventures, Tarrasque, Endurance28, Freeflow Ventures, and a syndicate of leading angel investors also participated in the round. The capital will be used to progress development of Holoclara’s orally available therapeutics into the clinic this year. The company additionally continues to advance its broader discovery engine to isolate and identify molecules with therapeutic potential from worms.